Serial Positron Emission Tomography Imaging of Changes in Amino Acid Metabolism in Low Grade Astrocytoma After Radio- and Chemotherapy —Case Report—

Kiyotaka Sato, Motonobu Kameyama, Takamasa Kayama, Takashi Yoshimoto, Kiichi Ishiwata, Masatoshi Ito

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

A 37-year-old male with mixed glioma was treated with combined radio and chemotherapy. The amino acid metabolism of the tumor site and normal brain was followed by positron emission tomography using [11C]methionine ([11C]Met). The accumulation of [11C]Met in the tumor decreased during therapy and slightly increased 7 months after completion of the therapy, but then decreased markedly. However, computed tomography revealed no notable changes. The contralateral gray matter also showed a gradual decrease of [11C]Met accumulation. These findings indicate that reduction of amino acid metabolism in the tumor continues after radiochemotherapy although neuroimaging reveals no further morphological changes. Such therapy also has long-term effects on normal brain tissue.

Original languageEnglish
Pages (from-to)808-812
Number of pages5
JournalNeurologia medico-chirurgica
Volume35
Issue number11
DOIs
Publication statusPublished - 1995

Keywords

  • [C]methionine
  • glioma
  • positron emission tomography
  • radiochemotherapy

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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