Sequential loss of heterozygosity in the progression of squamous cell carcinoma of the lung

C. Endo, M. Sagawa, M. Sato, Y. Chen, A. Sakurada, H. Aikawa, S. Takahashi, K. Usuda, Y. Saito, S. Fujimura

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Radiographically occult bronchogenic squamous cell carcinomas are early lung cancers that localize mainly in the bronchial wall, and are thought to be a good model for investigating genetic alterations through lung cancer progression. In order to elucidate sequential genetic changes in lung cancers, we analysed the incidence of allelic losses on chromosome regions 2q33, 3p21, 5q21, 7q31, 9p21 and 17p13 for 40 cases of radiographically occult bronchogenic squamous-cell carcinomas and 40 cases of advanced lung cancers microdissected. In this study we used eight microsatellite dinucleotide polymorphic markers. Frequent loss of heterozygosity (LOH) was observed on 3p21 (53%), 5q21 (44%) and 17p13 (61%) in roentgenographically occult bronchogenic squamous cell carcinomas. 2q, 7q and 9p were lost less frequently in both roentgenographically occult bronchogenic squamous cell carcinomas and advanced lung cancers. These results suggest that several tumour-suppressor genes are associated with lung cancer progression and that genetic changes on 3p21, 5q21 and 17p13 are early events.

Original languageEnglish
Pages (from-to)612-615
Number of pages4
JournalBritish Journal of Cancer
Volume78
Issue number5
DOIs
Publication statusPublished - 1998 Sep

Keywords

  • Loss of heterozygosity
  • Microdissection
  • Microsatellite polymorphism
  • Radiographically occult bronchogenic squamous-cell carcinoma
  • Tumorigenesis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Sequential loss of heterozygosity in the progression of squamous cell carcinoma of the lung'. Together they form a unique fingerprint.

Cite this