Abstract
We have identified three avian (chicken) Hu/elav family RNA-binding protein genes. cHuD and cHuC are expressed specifically in neurons of both the central and peripheral nervous systems. Although cHuA is expressed in a wide variety of tissues, including neurogenic precursor cells, it is transiently down-regulated, and is then re-expressed in maturing neurons. Misexpression of cHuD in cultured neural crest cells results in a dramatic increase in the proportion of cells exhibiting neuronal morphology, molecular markers for neurons, and neurotrophin dependence. These data confirm that cHuD protein is involved in regulating neuronal differentiation.
Original language | English |
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Pages (from-to) | 3449-3460 |
Number of pages | 12 |
Journal | Development |
Volume | 124 |
Issue number | 17 |
Publication status | Published - 1997 |
Externally published | Yes |
Keywords
- Apoptosis
- Chicken
- Elav
- Hu
- Neural crest
- Neurogenesis
- RNA-binding protein
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology