Sequential expression and role of Hu RNA-binding proteins during neurogenesis

Yoshio Wakamatsu, James A. Weston

Research output: Contribution to journalArticle

212 Citations (Scopus)

Abstract

We have identified three avian (chicken) Hu/elav family RNA-binding protein genes. cHuD and cHuC are expressed specifically in neurons of both the central and peripheral nervous systems. Although cHuA is expressed in a wide variety of tissues, including neurogenic precursor cells, it is transiently down-regulated, and is then re-expressed in maturing neurons. Misexpression of cHuD in cultured neural crest cells results in a dramatic increase in the proportion of cells exhibiting neuronal morphology, molecular markers for neurons, and neurotrophin dependence. These data confirm that cHuD protein is involved in regulating neuronal differentiation.

Original languageEnglish
Pages (from-to)3449-3460
Number of pages12
JournalDevelopment
Volume124
Issue number17
Publication statusPublished - 1997 Oct 25
Externally publishedYes

Keywords

  • Apoptosis
  • Chicken
  • Elav
  • Hu
  • Neural crest
  • Neurogenesis
  • RNA-binding protein

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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