Sequential assembly of the functional material micropatterns on the hydrogel sheet for constructing skeletal muscle cell-based assay system

Kuniaki Nagamine, Shingo Otani, Syuntaro Ito, Hirokazu Kaji, Makoto Kanzaki, Matsuhiko Nishizawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The functional material micropatterns-assembled hydrogel sheet has been prepared by means of sequential transfer technique to construct the skeletal muscle cell-based assay system. We demonstrated to construct micropatterned synaptic connection between motor neurons-skeletal muscle cells using this technique. Besides, assembly of the non-biological functional materials has also advantage to confer additional functions to a hydrogel assay system. The fluorescent microbeads were assembled onto a hydrogel as sensing elements of contractile force and metabolic activity of skeletal muscle cells. These flexible sensor sheets would be useful to study the relationship between exercise and metabolic activity of muscle in type 2 diabetes.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1054-1056
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012 Jan 1
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 2012 Oct 282012 Nov 1

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period12/10/2812/11/1

Keywords

  • Assembly
  • Bioassay
  • Hydrogel
  • Skeletal muscle cell

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Fingerprint Dive into the research topics of 'Sequential assembly of the functional material micropatterns on the hydrogel sheet for constructing skeletal muscle cell-based assay system'. Together they form a unique fingerprint.

Cite this