Sensitization of cells to ionizing radiation by chlorin e6Na

Yoshio Hosoi, Mieko Kawamura, Tatsuo Ido, Yoshihiro Takai, Keiichiro Ishii, Kenji Nemoto, Tetuya Ono, Shuichi Kimura, Kiyohiko Sakamoto

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We have investigated whether a hydrophilic photosensitizer, chlorin e6Na (Ce6Na), can sensitize cells to ionizing radiation. When V79-1 cells were pretreated with Ce6Na for 2 hr before receiving a dose of 2-14 Gy of irradiation, the cells became sensitive to X-irradiation. The sensitizing effect of Ce6Na depended on the dose of Ce6Na. The sensitizing effect also depended on the length of the treatment period before X-irradiation up to 4 hr, but not on the length of a treatment period after X-irradiation: Intracellular concentrations of Ce6Na were increased linearly after incubation with Ce6Na for periods of up to 4 h. The dose-modifying factor calculated from the survival curve was 1.25.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalRadiation Oncology Investigations
Volume6
Issue number4
DOIs
Publication statusPublished - 1998

Keywords

  • Chlorin eNa
  • Hematoporphyrin
  • Sensitizer
  • X-irradiation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging

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