Sensitivity of genera Porphyromonas and Prevotella to the bactericidal action of C-terminal domain of human CAP18 and its analogues

Emiko Isogai, H. Isogai, K. Matuo, K. Hirose, Y. Kowashi, K. Okumuara, M. Hirata

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)

    Abstract

    This paper reports the effect of the synthesized 27-amino acid sequence in the C-terminal domain of human CAP18 (hCAP18), a human cationic antibacterial protein or cathelicidin, on certain strains belonging to the genera Porophyromonas and Prevotella. The domain binds lipopolysaccharides (LPS) from Porophyromonas gingivalis and Porophyromonas circumdentaria as well as enterobacterial LPS. Two analogues of hCAP18, designated LL/CAP18 and FF/CAP18, were also tested to determine whether additional activity was obtained. The analogue peptides replaced with hydrophobic and cationic amino acid residues showed more potent bactericidal and LPS-binding activities than the original one.

    Original languageEnglish
    Pages (from-to)329-332
    Number of pages4
    JournalOral Microbiology and Immunology
    Volume18
    Issue number5
    DOIs
    Publication statusPublished - 2003 Oct

    Keywords

    • Antimicrobial activity
    • LPS-binding activity
    • Lipopolysaccharide
    • Porphyromonas
    • hCAP18-derived peptides

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Dentistry(all)
    • Microbiology (medical)

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