Sensitivity of genera Porphyromonas and Prevotella to the bactericidal action of C-terminal domain of human CAP18 and its analogues

Emiko Isogai, H. Isogai, K. Matuo, K. Hirose, Y. Kowashi, K. Okumuara, M. Hirata

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

This paper reports the effect of the synthesized 27-amino acid sequence in the C-terminal domain of human CAP18 (hCAP18), a human cationic antibacterial protein or cathelicidin, on certain strains belonging to the genera Porophyromonas and Prevotella. The domain binds lipopolysaccharides (LPS) from Porophyromonas gingivalis and Porophyromonas circumdentaria as well as enterobacterial LPS. Two analogues of hCAP18, designated LL/CAP18 and FF/CAP18, were also tested to determine whether additional activity was obtained. The analogue peptides replaced with hydrophobic and cationic amino acid residues showed more potent bactericidal and LPS-binding activities than the original one.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalOral Microbiology and Immunology
Volume18
Issue number5
DOIs
Publication statusPublished - 2003 Oct

Keywords

  • Antimicrobial activity
  • LPS-binding activity
  • Lipopolysaccharide
  • Porphyromonas
  • hCAP18-derived peptides

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Dentistry(all)
  • Microbiology (medical)

Fingerprint Dive into the research topics of 'Sensitivity of genera Porphyromonas and Prevotella to the bactericidal action of C-terminal domain of human CAP18 and its analogues'. Together they form a unique fingerprint.

Cite this