Sensitive 13C-13C correlation spectra of amyloid fibrils at very high spinning frequencies and magnetic fields

Markus Weingarth, Yuichi Masuda, K. Takegoshi, Geoffrey Bodenhausen, Piotr Tekely

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Sensitive 2D solid-state 13C-13C correlation spectra of amyloid β fibrils have been recorded at very fast spinning frequencies and very high magnetic fields. It is demonstrated that PARIS-xy recoupling using moderate rf amplitudes can provide structural information by promoting efficient magnetization transfer even under such challenging experimental conditions. Furthermore, it has been shown both experimentally and by numerical simulations that the method is not very sensitive to dipolar truncation effects and can reveal direct transfer across distances of about 3.5-4Å .

Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalJournal of biomolecular NMR
Volume50
Issue number2
DOIs
Publication statusPublished - 2011 Jun

Keywords

  • Amyloid β
  • Dipolar truncation
  • Fibrils
  • PARIS-xy dipolar recoupling
  • Solid-state NMR
  • Ultra-high magnetic field

ASJC Scopus subject areas

  • Biochemistry
  • Spectroscopy

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