Sensitive ferrocene reagents for derivatization of amines for high-performance liquid chromatography with electrochemical detection

Kazutake Shimada, Tomoyuki Oe, Makoto Tanaka, Toshio Nambara

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Six reagents possessing ferrocene as an electrophore were prepared and evaluated for pre-column derivatization of amino compounds for their determination by high-performance liquid chromatography with electrochemical detection. The utility of these reagents was investigated employing phenethylamine as a model compound. Among these six, N-succinimidyl 3-ferrocenylpropionate was the best with respect to reactivity, stability and electrochemical properties. The developed method was applied to the determination of putrescine formed from ornithine by ornithine decarboxylase.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalJournal of Chromatography B: Biomedical Sciences and Applications
Volume487
Issue numberC
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Chemistry(all)

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