Sensing caspase-1 activity using activatable 19F MRI nanoprobes with improved turn-on kinetics

Kazuki Akazawa, Fuminori Sugihara, Masafumi Minoshima, Shin Mizukami, Kazuya Kikuchi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Activatable 19F MRI nanoprobes for sensing caspase-1 activity were developed. Tandem repetition of substrate peptide sequences improved the turn-on response of nanoprobes, allowing detection of caspase-1 activity by 19F MRI. In vivo immune response was successfully imaged using the new nanoprobe.

Original languageEnglish
Pages (from-to)11785-11788
Number of pages4
JournalChemical Communications
Volume54
Issue number83
DOIs
Publication statusPublished - 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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