Semi-interpenetrating polymer networks composed of biocompatible phospholipid polymer and segmented polyurethane

Yasuhiko Iwasaki, Yoshiyuki Aiba, Nobuyuki Morimoto, Nobuo Nakabayashi, Kazuhiko Ishihara

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers, which have excellent biocompatibility, have been receiving increasing attention in biomedical and bioengineering fields; however, the mechanical strength of the hydrated MPC polymers is not sufficient for use in these fields as a bulk material. Therefore, we hypothesized that a novel material might be realized by reinforcing the MPC polymer network with segmented polyurethane (SPU). Semi-interpenetrating polymer networks (IPNs) composed of crosslinked MPC polymer and SPU were prepared. The mechanical properties of the IPN membrane were significantly improved compared with those of the MPC polymer membrane. Three-dimensional polymer networks of the MPC polymer in the IPNs were observed after solvent extraction of SPU. An X-ray photoelectron spectrum analysis revealed that the MPC units were exposed on the IPN surface. When the IPN was alternately soaked in water and ethanol, the swelling ratio was found to be completely reversible and no disintegration of the network structure was observed. The permeation coefficient of 1,4-di(2-hydroxyethoxy)benzene through the IPN membrane was 1.11 x 10-7 cm-2s-1 . The amount of adsorbed protein and the number of adherent platelets on the IPN membrane were effectively reduced compared with those on SPU. We concluded that IPNs composed of the MPC polymer and SPU are a new bulk biomaterial, which possesses both blood compatibility and good mechanical properties. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish
Pages (from-to)701-708
Number of pages8
JournalJournal of Biomedical Materials Research
Volume52
Issue number4
DOIs
Publication statusPublished - 2000 Dec

Keywords

  • Biocompatibility
  • Hydrogel
  • Interpenetrating polymer networks
  • Phospholipid polymer
  • Protein adsorption
  • Segmented polyurethane

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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