Self-spreading supported lipid bilayer passing through single nanogap structure: Effect of position of dyes in lipid molecules

Yoshiaki Kashimura, Kazuaki Furukawa, Keiichi Torimitsu

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We report the self-spreading behavior of single lipid bilayers containing 7-nitrobenz-2-oxa-1, 3-diazol-4-yl (NBD) fluorophores on a patterned surface equipped with a single nanogap. We found that the behavior of the fluorophores around the nanogap depended on the position of the dyes in the lipid molecules. For acyl chain-labeled lipids, the fluorescence intensities decreased discontinuously before and after they passed through the nanogap, whereas little decrease was observed for a headgroup-labeled lipid. A possible mechanism can be explained in terms of the reorientation of dyes in a lipid bilayer. Acyl chain-labeled NBD fluorophores are known to loop back to a lipid-water interface in a lipid bilayer. Since this effect makes an effective size of the lipid molecule larger, dye molecules easily suffer from steric hindrance when they pass through a nanogap leading to the fluorescence intensity reduction.

Original languageEnglish
Article number04DL15
JournalJapanese journal of applied physics
Volume49
Issue number4 PART 2
DOIs
Publication statusPublished - 2010 Apr 1
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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