Self-replication of DNA rings

Junghoon Kim, Junwye Lee, Shogo Hamada, Satoshi Murata, Sung Ha Park

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Biology provides numerous examples of self-replicating machines, but artificially engineering such complex systems remains a formidable challenge. In particular, although simple artificial self-replicating systems including wooden blocks, magnetic systems, modular robots and synthetic molecular systems have been devised, such kinematic self-replicators are rare compared with examples of theoretical cellular self-replication. One of the principal reasons for this is the amount of complexity that arises when you try to incorporate self-replication into a physical medium. In this regard, DNA is a prime candidate material for constructing self-replicating systems due to its ability to self-assemble through molecular recognition. Here, we show that DNA T-motifs, which self-assemble into ring structures, can be designed to self-replicate through toehold-mediated strand displacement reactions. The inherent design of these rings allows the population dynamics of the systems to be controlled. We also analyse the replication scheme within a universal framework of self-replication and derive a quantitative metric of the self-replicability of the rings.

Original languageEnglish
Pages (from-to)528-533
Number of pages6
JournalNature Nanotechnology
Volume10
Issue number6
DOIs
Publication statusPublished - 2015 Jun 6

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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    Kim, J., Lee, J., Hamada, S., Murata, S., & Ha Park, S. (2015). Self-replication of DNA rings. Nature Nanotechnology, 10(6), 528-533. https://doi.org/10.1038/nnano.2015.87