Self-organization of a stable pore structure in a phospholipid bilayer

Kenichiro Koshiyama, Takeru Yano, Tetsuya Kodama

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

We demonstrate the self-organization process of a stable pore structure in a phospholipid bilayer by unsteady and nonequilibrium molecular dynamics simulations. The simulation is started from an initial state including some amount of water molecules in its hydrophobic region, which is a model of a cell membrane stimulated by ultrasound radiation for the membrane permeabilization (sonoporation). We show that, in several nanoseconds, the bilayer-water system can spontaneously develop into a water-filled pore structure without any mechanical and electrical forcing from outside, when the initial number of water molecules in the hydrophobic region exceeds a critical value. The increase in the initial number of water molecules enhances the probability of pore formation, and sometimes induces the formation of transient micellelike structures of phospholipid molecules.

Original languageEnglish
Article number018105
JournalPhysical Review Letters
Volume105
Issue number1
DOIs
Publication statusPublished - 2010 Jul 2

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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