Self-organaized tubular-linked liposome network

Shin Ichiro M. Nomura, Kazunari Akiyoshi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Recently, we have identified a microscopic network consisting of a spontaneously-formed, three-dimensional tubular-linked liposome structure. In the presence of various gangliosides or cholesterol, the dispersed spherical liposomes drastically and spontaneously altered their forms to create a tubular-linked network. The tubular structures were identified as being hydrophilic tunnels (∼200 nm in diameter and 20-100 μm in length). It is notable that the network formed by cholesterol system can be dismantled to the dispersed liposomes by addition of methyl-β-cyclodextrin. Such a lipidic network can encapsulate biomacromolecules (nucleic acids) in the internal hydrophilic spaces of the vesicles and tubules. The hydrophilic molecules of enzymes or substrates could pass through the tubule of the network. This result could contribute to the construction of a chemical microreactor system such as connectable artificial cells.

Original languageEnglish
Title of host publication2006 IEEE International Symposium on Micro-Nano Mechanical and Human Science, MHS
DOIs
Publication statusPublished - 2006 Dec 1
Externally publishedYes
Event2006 IEEE International Symposium on Micro-Nano Mechanical and Human Science, MHS - Nagoya, Japan
Duration: 2006 Nov 52006 Nov 8

Publication series

Name2006 IEEE International Symposium on Micro-Nano Mechanical and Human Science, MHS

Other

Other2006 IEEE International Symposium on Micro-Nano Mechanical and Human Science, MHS
CountryJapan
CityNagoya
Period06/11/506/11/8

ASJC Scopus subject areas

  • Computational Mechanics
  • Control and Systems Engineering
  • Human Factors and Ergonomics

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