Self-assembled microspheres driven by dipole-dipole interactions: UCST-type transition in water

Nobuyuki Morimoto; Kanna Muramatsu; Tetsuichi Wazawa; Yuichi Inoue; Makoto Suzuki

doi:10.1002/marc.201300798

Self-assembled microspheres driven by dipole-dipole interactions: UCST-type transition in water

Nobuyuki Morimoto, Kanna Muramatsu, Tetsuichi Wazawa, Yuichi Inoue, Makoto Suzuki

Research output: Contribution to journal › Article

15 Citations (Scopus)

Abstract

A double hydrophilic block copolymer, poly(ethylene glycol)-poly(3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate) (PEG-SB), is synthesized by reversible addition-fragmentation transfer (RAFT) polymerization using PEG methyl ether (4-cyano-4-pentanoate dodecyl trithiocarbonate) as a chain transfer agent. PEG-SB forms multi-layered microspheres with dipole-dipole interactions of the SB side chains as the driving force. The PEG-SB polymers show an upper critical solution temperature (UCST) and the UCST is controllable by the polymerization degree. The PEG-SB microspheres are dissociated above the UCST and then monodispersed microspheres (∼1 μm) are obtained when the solution temperature is decreased below the UCST again. The disassociation/ association of the microspheres is also controllable using the concentration of NaCl. These multi-responsive microspheres could be a powerful tool in the field of nano-biotechnology.

Original language	English
Pages (from-to)	103-108
Number of pages	6
Journal	Macromolecular Rapid Communications
Volume	35
Issue number	1
DOIs	https://doi.org/10.1002/marc.201300798
Publication status	Published - 2014 Jan 1

Keywords

dipole-dipole interactions
microspheres
self-assembly
stimuli-sensitive polymers
upper critical solution temperature

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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Morimoto, N., Muramatsu, K., Wazawa, T., Inoue, Y., & Suzuki, M. (2014). Self-assembled microspheres driven by dipole-dipole interactions: UCST-type transition in water. Macromolecular Rapid Communications, 35(1), 103-108. https://doi.org/10.1002/marc.201300798

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AU - Suzuki, Makoto

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N2 - A double hydrophilic block copolymer, poly(ethylene glycol)-poly(3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate) (PEG-SB), is synthesized by reversible addition-fragmentation transfer (RAFT) polymerization using PEG methyl ether (4-cyano-4-pentanoate dodecyl trithiocarbonate) as a chain transfer agent. PEG-SB forms multi-layered microspheres with dipole-dipole interactions of the SB side chains as the driving force. The PEG-SB polymers show an upper critical solution temperature (UCST) and the UCST is controllable by the polymerization degree. The PEG-SB microspheres are dissociated above the UCST and then monodispersed microspheres (∼1 μm) are obtained when the solution temperature is decreased below the UCST again. The disassociation/ association of the microspheres is also controllable using the concentration of NaCl. These multi-responsive microspheres could be a powerful tool in the field of nano-biotechnology.

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