Self-assembled microspheres driven by dipole-dipole interactions: UCST-type transition in water

Nobuyuki Morimoto; Kanna Muramatsu; Tetsuichi Wazawa; Yuichi Inoue; Makoto Suzuki

doi:10.1002/marc.201300798

Self-assembled microspheres driven by dipole-dipole interactions: UCST-type transition in water

Nobuyuki Morimoto, Kanna Muramatsu, Tetsuichi Wazawa, Yuichi Inoue, Makoto Suzuki

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A double hydrophilic block copolymer, poly(ethylene glycol)-poly(3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate) (PEG-SB), is synthesized by reversible addition-fragmentation transfer (RAFT) polymerization using PEG methyl ether (4-cyano-4-pentanoate dodecyl trithiocarbonate) as a chain transfer agent. PEG-SB forms multi-layered microspheres with dipole-dipole interactions of the SB side chains as the driving force. The PEG-SB polymers show an upper critical solution temperature (UCST) and the UCST is controllable by the polymerization degree. The PEG-SB microspheres are dissociated above the UCST and then monodispersed microspheres (∼1 μm) are obtained when the solution temperature is decreased below the UCST again. The disassociation/ association of the microspheres is also controllable using the concentration of NaCl. These multi-responsive microspheres could be a powerful tool in the field of nano-biotechnology.

Original language	English
Pages (from-to)	103-108
Number of pages	6
Journal	Macromolecular Rapid Communications
Volume	35
Issue number	1
DOIs	https://doi.org/10.1002/marc.201300798
Publication status	Published - 2014 Jan

Keywords

dipole-dipole interactions
microspheres
self-assembly
stimuli-sensitive polymers
upper critical solution temperature

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1002/marc.201300798

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title = "Self-assembled microspheres driven by dipole-dipole interactions: UCST-type transition in water",

abstract = "A double hydrophilic block copolymer, poly(ethylene glycol)-poly(3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate) (PEG-SB), is synthesized by reversible addition-fragmentation transfer (RAFT) polymerization using PEG methyl ether (4-cyano-4-pentanoate dodecyl trithiocarbonate) as a chain transfer agent. PEG-SB forms multi-layered microspheres with dipole-dipole interactions of the SB side chains as the driving force. The PEG-SB polymers show an upper critical solution temperature (UCST) and the UCST is controllable by the polymerization degree. The PEG-SB microspheres are dissociated above the UCST and then monodispersed microspheres (∼1 μm) are obtained when the solution temperature is decreased below the UCST again. The disassociation/ association of the microspheres is also controllable using the concentration of NaCl. These multi-responsive microspheres could be a powerful tool in the field of nano-biotechnology.",

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author = "Nobuyuki Morimoto and Kanna Muramatsu and Tetsuichi Wazawa and Yuichi Inoue and Makoto Suzuki",

year = "2014",

month = jan,

doi = "10.1002/marc.201300798",

language = "English",

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T2 - UCST-type transition in water

AU - Morimoto, Nobuyuki

AU - Muramatsu, Kanna

AU - Wazawa, Tetsuichi

AU - Inoue, Yuichi

AU - Suzuki, Makoto

PY - 2014/1

Y1 - 2014/1

N2 - A double hydrophilic block copolymer, poly(ethylene glycol)-poly(3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate) (PEG-SB), is synthesized by reversible addition-fragmentation transfer (RAFT) polymerization using PEG methyl ether (4-cyano-4-pentanoate dodecyl trithiocarbonate) as a chain transfer agent. PEG-SB forms multi-layered microspheres with dipole-dipole interactions of the SB side chains as the driving force. The PEG-SB polymers show an upper critical solution temperature (UCST) and the UCST is controllable by the polymerization degree. The PEG-SB microspheres are dissociated above the UCST and then monodispersed microspheres (∼1 μm) are obtained when the solution temperature is decreased below the UCST again. The disassociation/ association of the microspheres is also controllable using the concentration of NaCl. These multi-responsive microspheres could be a powerful tool in the field of nano-biotechnology.

AB - A double hydrophilic block copolymer, poly(ethylene glycol)-poly(3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate) (PEG-SB), is synthesized by reversible addition-fragmentation transfer (RAFT) polymerization using PEG methyl ether (4-cyano-4-pentanoate dodecyl trithiocarbonate) as a chain transfer agent. PEG-SB forms multi-layered microspheres with dipole-dipole interactions of the SB side chains as the driving force. The PEG-SB polymers show an upper critical solution temperature (UCST) and the UCST is controllable by the polymerization degree. The PEG-SB microspheres are dissociated above the UCST and then monodispersed microspheres (∼1 μm) are obtained when the solution temperature is decreased below the UCST again. The disassociation/ association of the microspheres is also controllable using the concentration of NaCl. These multi-responsive microspheres could be a powerful tool in the field of nano-biotechnology.

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KW - self-assembly

KW - stimuli-sensitive polymers

KW - upper critical solution temperature

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Self-assembled microspheres driven by dipole-dipole interactions: UCST-type transition in water

Abstract

Keywords

ASJC Scopus subject areas

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