Self-aldol condensation of unmodified aldehyde in supercritical carbon dioxide catalyzed by amine grafted on silica

Hisahiro Hagiwara, Jun Hamaya, Takashi Hoshi, Chiaki Yokoyama

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Self-aldol condensation of an unmodified aldehyde has been effected by 3-N-methylaminopropylated silica as a catalyst in supercritical carbon dioxide, to give an α,β-unsaturated aldehyde (enal). Aldehydes having acid or base-sensitive substituents provided desired enals.

Original languageEnglish
Pages (from-to)393-395
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number3
DOIs
Publication statusPublished - 2005 Jan 17

Keywords

  • Aldehydes
  • Aldol reactions
  • Supercritical fluids
  • Supported reagents

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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