TY - JOUR
T1 - Selenoprotein P; P for plasma, prognosis, prophylaxis, and more
AU - Tsutsumi, Ryouhei
AU - Saito, Yoshiro
N1 - Funding Information:
Acknowledgments This work was supported by the Japan Society for the Promotion of Science (JSPS) Grants-in-Aid
Funding Information:
This work was supported by the Japan Society for the Promotion of Science (JSPS) Grants-in-Aid for Scientific Research (19K21238 to R.T.; 17H03821 and 19K22480 to Y.S.) and by the Takeda Science Foundation (to R.T.).
Publisher Copyright:
© 2020 The Pharmaceutical Society of Japan
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Selenoprotein P (SeP) is one of the 25 human selenocysteine (Sec)-containing proteins, and is generally thought to function as a plasma carrier of the trace element selenium in the body. Recent studies, however, indicate unsuspected pivotal roles of SeP in human diseases, particularly in type 2 diabetes mellitus (T2DM) and pulmonary arterial hypertension (PAH). In this review, we will summarize the characteristics of SeP and recent advances in the field, especially focusing on the emerging roles of SeP in pathophysiological conditions. We will also discuss potential medical/pharmaceutical applications targeting SeP.
AB - Selenoprotein P (SeP) is one of the 25 human selenocysteine (Sec)-containing proteins, and is generally thought to function as a plasma carrier of the trace element selenium in the body. Recent studies, however, indicate unsuspected pivotal roles of SeP in human diseases, particularly in type 2 diabetes mellitus (T2DM) and pulmonary arterial hypertension (PAH). In this review, we will summarize the characteristics of SeP and recent advances in the field, especially focusing on the emerging roles of SeP in pathophysiological conditions. We will also discuss potential medical/pharmaceutical applications targeting SeP.
KW - Pulmonary arterial hypertension
KW - Selenium
KW - Selenoprotein P
KW - Type 2 diabetes mellitus
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U2 - 10.1248/bpb.b19-00837
DO - 10.1248/bpb.b19-00837
M3 - Review article
C2 - 32115498
AN - SCOPUS:85080840338
VL - 43
SP - 366
EP - 374
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 3
ER -
