Selenium efficiently depressed toxic side effect of cis-diamminedichloroplatinum

Akira Naganuma, M. Satoh, M. Yokoyama, N. Imura

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Effect of selenium on toxic side effects of cis-diamminedichloroplatinum (Cisplatin; CDDP) which is a potent anticancer drug containing platinum was examined. Remarkable protective effects of selenium against lethal and renal toxicity of CDDP were observed when selenite was administered to mice once a day after single injection of a lethal dose of CDDP. On the other hand antitumor activity of CDDP was hardly depressed by selenite.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume42
Issue number1
Publication statusPublished - 1983 Dec 1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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