Effect of selenium on toxic side effects of cis-diamminedichloroplatinum (Cisplatin; CDDP) which is a potent anticancer drug containing platinum was examined. Remarkable protective effects of selenium against lethal and renal toxicity of CDDP were observed when selenite was administered to mice once a day after single injection of a lethal dose of CDDP. On the other hand antitumor activity of CDDP was hardly depressed by selenite.
|Number of pages||8|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|Publication status||Published - 1983|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)