Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON Mice

Mototsugu Nagao, Jonathan Lou S. Esguerra, Anna Wendt, Akira Asai, Hitoshi Sugihara, Shinichi Oikawa, Lena Eliasson

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)


The polygenic background of selectively bred diabetes models mimics the etiology of type 2 diabetes. So far, three different rodent models (Goto-Kakizaki rats, Nagoya-Shibata-Yasuda mice, and Oikawa-Nagao mice) have been established in the diabetes research field by continuous selective breeding for glucose tolerance from outbred rodent stocks. The origin of hyperglycemia in these rodents is mainly insulin secretion deficiency from the pancreatic β-cells and mild insulin resistance in insulin target organs. In this chapter, we summarize backgrounds and phenotypes of these rodent models to highlight their importance in diabetes research. Then, we introduce experimental methodologies to evaluate β-cell exocytosis as a putative common defect observed in these rodent models.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages30
Publication statusPublished - 2020

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • Capacitance measurement
  • Exocytosis
  • Goto-Kakizaki rats
  • Insulin secretion
  • Islets
  • Nagoya-Shibata-Yasuda mice
  • Oikawa-Nagao mice
  • β-Cells

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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