Selective reduction of diffusion anisotropy in white matter of Alzheimer disease brains measured by 3.0 Tesla magnetic resonance imaging

Masanori Taketomi, Nagatoki Kinoshita, Kazushi Kimura, Masaaki Kitada, Toru Noda, Hiroaki Asou, Takashi Nakamura, Chizuka Ide

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

Alzheimer disease (AD) is pathologically characterized by cortical atrophy. Changes in the white matter and their relation to the pathogenesis of AD remain to be studied. To quantitatively investigate the integrity and organization of white matter fiber tracts in patients with AD, we used diffusion tensor (DT) imaging to study the diffusion anisotropy of white matter regions. DT imaging was performed using a 3.0 Tesla magnetic resonance scanner in ten probable AD patients with no or only mild changes in the white matter in T2 weighted magnetic resonance imagings and ten group-matched controls. The values of fractional anisotropy were significantly lower in the temporal subcortical white matter, posterior part of the corpus callosum, and anterior and posterior cingulate bundles in patients with AD compared with controls. Possible relationships of these selective impairments in the white matter with pathological changes in the poterior cerebral cortices and hippocampus were discussed.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalNeuroscience Letters
Volume332
Issue number1
DOIs
Publication statusPublished - 2002 Oct 25

Keywords

  • 3.0 Tesla magnetic resonance imaging (magnetic resonance imaging)
  • Alzheimer disease
  • Diffusion tensor imaging
  • White matter

ASJC Scopus subject areas

  • Neuroscience(all)

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