Selective reaction to a flipping cytidine of the duplex DNA mediated by triple helix formation

Fumi Nagatsugi, Daisaku Usui, Takeshi Kawasaki, Minoru Maeda, Shigeki Sasaki

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

A new nucleoside derivative (2) with a butyl spacer between the sugar part and the 2-amino-6-vinylpurine motif has been synthesized. The triplex-forming oligodeoxynucleotide incorporating 2 has achieved strand- and cytidine-selective cross-linking reaction to the G-C target site mediated by triple helix formation. It has been suggested that 2 reacts with a flipping cytidine at the target site.

Original languageEnglish
Pages (from-to)343-345
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number3
DOIs
Publication statusPublished - 2001 Feb 12

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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