Selective cross-linking to the adenine of the TA interrupting site within the triple helix

Fumi Nagatsugi, Yoshihisa Matsuyama, Minoru Maeda, Shigeki Sasaki

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The triplex-forming oligonucleotide incorporating the new nucleoside derivative (2) that connects the 2-amino-6-vinylpurine moiety to the 2-deoxyribose unit with an ethyl spacer has exhibited highly selective cross-linking reaction to the adenine of the TA interrupting site within the triple helix.

Original languageEnglish
Pages (from-to)487-489
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number3
DOIs
Publication statusPublished - 2002 Feb 11
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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