TY - JOUR
T1 - Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors
AU - Dai, Hongmei
AU - Kaneko, Kenya
AU - Kato, Hiroshi
AU - Fujii, Satoshi
AU - Jing, Yuhong
AU - Xu, Ajing
AU - Sakurai, Eiko
AU - Kato, Motohisa
AU - Okamura, Nobuyuki
AU - Kuramasu, Atsuo
AU - Yanai, Kazuhiko
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for scientific research (#17390156; #14370027; #12557007) from the Japan Society of Promotion of Science (JSPS) and a 21st Century COE program (Bio-nano-technology) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2007/2
Y1 - 2007/2
N2 - Previous pharmacological experiments provide conflicting findings that describe both facilitatory and inhibitory effects of neuronal histamine on learning and memory. Here, we examined learning and memory and synaptic plasticity in mice with a null mutation of gene coding histamine H1 or H2 receptor in order to clarify the role of these receptors in learning and memory processes. Learning and memory were evaluated by several behavioral tasks including object recognition, Barnes maze and fear conditioning. These behavioral tasks are highly dependent on the function of prefrontal cortex, hippocampus or amygdala. Object recognition and Barnes maze performance were significantly impaired in both H1 receptor gene knockout (H1KO) and H2 receptor gene knockout (H2KO) mice when compared to the respective wild-type (WT) mice. Conversely, both H1KO and H2KO mice showed better auditory and contextual freezing acquisition than their respective WT mice. Furthermore, we also examined long-term potentiation (LTP) in the CA1 area of hippocampus in H1KO and H2KO mice and their respective WT mice. LTP in the CA1 area of hippocampus was significantly reduced in both H1KO and H2KO mice when compared with their respective WT mice. In conclusion, our results demonstrate that both H1 and H2 receptors are involved in learning and memory processes for which the frontal cortex, amygdala and hippocampus interact.
AB - Previous pharmacological experiments provide conflicting findings that describe both facilitatory and inhibitory effects of neuronal histamine on learning and memory. Here, we examined learning and memory and synaptic plasticity in mice with a null mutation of gene coding histamine H1 or H2 receptor in order to clarify the role of these receptors in learning and memory processes. Learning and memory were evaluated by several behavioral tasks including object recognition, Barnes maze and fear conditioning. These behavioral tasks are highly dependent on the function of prefrontal cortex, hippocampus or amygdala. Object recognition and Barnes maze performance were significantly impaired in both H1 receptor gene knockout (H1KO) and H2 receptor gene knockout (H2KO) mice when compared to the respective wild-type (WT) mice. Conversely, both H1KO and H2KO mice showed better auditory and contextual freezing acquisition than their respective WT mice. Furthermore, we also examined long-term potentiation (LTP) in the CA1 area of hippocampus in H1KO and H2KO mice and their respective WT mice. LTP in the CA1 area of hippocampus was significantly reduced in both H1KO and H2KO mice when compared with their respective WT mice. In conclusion, our results demonstrate that both H1 and H2 receptors are involved in learning and memory processes for which the frontal cortex, amygdala and hippocampus interact.
KW - H1 and H2 receptor
KW - Histamine
KW - Learning and memory
KW - Long-term potentiation (LTP)
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U2 - 10.1016/j.neures.2006.10.020
DO - 10.1016/j.neures.2006.10.020
M3 - Article
C2 - 17145090
AN - SCOPUS:33846562485
VL - 57
SP - 306
EP - 313
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
IS - 2
ER -