Selective capture of 1α,25-(OH)2-previtamin D3 utilizing polymer-supported trialkylsilyl triflate in the synthesis of 1α,25-(OH)2-vitamin D3

Takayuki Doi; Masahito Yoshida; Ichiro Hijikuro; Takashi Takahashi

doi:10.1016/j.tetlet.2004.05.125

Selective capture of 1α,25-(OH)₂-previtamin D₃ utilizing polymer-supported trialkylsilyl triflate in the synthesis of 1α,25-(OH)₂-vitamin D₃

Takayuki Doi, Masahito Yoshida, Ichiro Hijikuro, Takashi Takahashi

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Catch and release method utilizing polymer-support was investigated in the separation of 1α,25-(OH)₂ pre- and provitamin D₃. Polymer-supported alkyldiisopropylsilyl triflate selectively captured the previtamin D₃ from a 26:74 mixture of pre- and provitamin D ₃ produced by photoisomerization of provitamin D₃.

Original language	English
Pages (from-to)	5727-5729
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	29
DOIs	https://doi.org/10.1016/j.tetlet.2004.05.125
Publication status	Published - 2004 Jul 12

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Selective capture of 1α,25-(OH)2-previtamin D3 utilizing polymer-supported trialkylsilyl triflate in the synthesis of 1α,25-(OH)2-vitamin D3",

abstract = "Catch and release method utilizing polymer-support was investigated in the separation of 1α,25-(OH)2 pre- and provitamin D3. Polymer-supported alkyldiisopropylsilyl triflate selectively captured the previtamin D3 from a 26:74 mixture of pre- and provitamin D 3 produced by photoisomerization of provitamin D3.",

author = "Takayuki Doi and Masahito Yoshida and Ichiro Hijikuro and Takashi Takahashi",

year = "2004",

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language = "English",

volume = "45",

pages = "5727--5729",

journal = "Tetrahedron Letters",

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T1 - Selective capture of 1α,25-(OH)2-previtamin D3 utilizing polymer-supported trialkylsilyl triflate in the synthesis of 1α,25-(OH)2-vitamin D3

AU - Doi, Takayuki

AU - Yoshida, Masahito

AU - Hijikuro, Ichiro

AU - Takahashi, Takashi

PY - 2004/7/12

Y1 - 2004/7/12

N2 - Catch and release method utilizing polymer-support was investigated in the separation of 1α,25-(OH)2 pre- and provitamin D3. Polymer-supported alkyldiisopropylsilyl triflate selectively captured the previtamin D3 from a 26:74 mixture of pre- and provitamin D 3 produced by photoisomerization of provitamin D3.

AB - Catch and release method utilizing polymer-support was investigated in the separation of 1α,25-(OH)2 pre- and provitamin D3. Polymer-supported alkyldiisopropylsilyl triflate selectively captured the previtamin D3 from a 26:74 mixture of pre- and provitamin D 3 produced by photoisomerization of provitamin D3.

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DO - 10.1016/j.tetlet.2004.05.125

M3 - Article

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EP - 5729

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 29

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