Selective alkylation of parallel G-quadruplex structure

Kazumitsu Onizuka, Erchissaran Ganbold, Yue Ma, Shogo Sasaki, Madoka E. Hazemi, Yutong Chen, Norihiro Sato, Mamiko Ozawa, Kazuo Nagasawa, Fumi Nagatsugi

Research output: Contribution to journalArticlepeer-review

Abstract

The selective alkylation of nucleic acids is important for a medicinal approach and biological study. We now report a novel selective alkylation of the parallel G-quadruplex structure using the conjugate of the macrocyclic hexaoxazole L2G2-6OTD-1M1PA and vinyl-quinazolinone-S(O)Me (6OTD-VQ-S(O)Me).

Original languageEnglish
Pages (from-to)2891-2894
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume19
Issue number13
DOIs
Publication statusPublished - 2021 Apr 7

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Selective alkylation of parallel G-quadruplex structure'. Together they form a unique fingerprint.

Cite this