Selection for high and low oxygen consumption altered hepatic mitochondrial energy efficiency in mice

Yu Hong, Astrid Ardiyanti, Motoi Kikusato, Tomoyuki Shimazu, Masaaki Toyomizu, Keiichi Suzuki

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)


    Selection for high (H) and low (L) oxygen consumption (OC) as an indirect estimation of maintenance energy requirement was determined. Feed intake and body weight were measured and feed conversion ratio (FCR) of 4-8-week-old mice was calculated. Respiratory activity of hepatic mitochondria was measured at 12 weeks. Total feed intake (H: 103.74g, L: 97.92g, P<0.01), daily feed intake (H: 3.70g/day, L: 3.50g/day, P<0.01) and FCR (H: 18.79, L: 15.50, P<0.01) were significantly different between lines. The line by sex interaction was significant for FCR. No line differences were observed in males; and the FCR of the H line was greater than in the L line in females. H line mice had the highest hepatic mitochondrial respiratory activity in state 2 (P<0.01), the highest uncoupled respiratory rate of mitochondria in the presence of an uncoupling agent (P<0.001), and the mitochondrial proton leak. The adenosine diphosphate/ O ratio was highest in the L line (P<0.05). This suggests that the selection for high and low OC induced differences in basal mitochondrial respiration and basal metabolism, resulting in difference in FCR between H and L lines.

    Original languageEnglish
    Pages (from-to)818-825
    Number of pages8
    JournalAnimal Science Journal
    Issue number9
    Publication statusPublished - 2015 Sep 1


    • Mice
    • Mitochondria
    • Oxygen consumption
    • Selection

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)


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