Select interneuron clusters determine female sexual receptivity in Drosophila

Akira Sakurai, Masayuki Koganezawa, Kei Ichiro Yasunaga, Kazuo Emoto, Daisuke Yamamoto

    Research output: Contribution to journalArticlepeer-review

    23 Citations (Scopus)

    Abstract

    Female Drosophila with the spinster mutation repel courting males and rarely mate. Here we show that the non-copulating phenotype can be recapitulated by the elimination of spinster functions from either spin-A or spin-D neuronal clusters, in the otherwise wild-type (spinster heterozygous) female brain. Spin-D corresponds to the olfactory projection neurons with dendrites in the antennal lobe VA1v glomerulus that is fruitless-positive, sexually dimorphic and responsive to fly odour. Spin-A is a novel local neuron cluster in the suboesophageal ganglion, which is known to process contact chemical pheromone information and copulation-related signals. A slight reduction in spinster expression to a level with a minimal effect is sufficient to shut off female sexual receptivity if the dominant-negative mechanistic target of rapamycin is simultaneously expressed, although the latter manipulation alone has only a marginal effect. We propose that spin-mediated mechanistic target of rapamycin signal transduction in these neurons is essential for females to accept the courting male.

    Original languageEnglish
    Article number1825
    JournalNature communications
    Volume4
    DOIs
    Publication statusPublished - 2013 Jun 10

    ASJC Scopus subject areas

    • Chemistry(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Physics and Astronomy(all)

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