Secretin receptor involvement in prion-infected cells and animals

Tomohiro Kimura, Keiko Nishizawa, Ayumi Oguma, Yuki Nishimura, Yuji Sakasegawa, Kenta Teruya, Ichiko Nishijima, Katsumi Doh-Ura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Abstract The cellular mechanisms behind prion biosynthesis and metabolism remain unclear. Here we show that secretin signaling via the secretin receptor regulates abnormal prion protein formation in prion-infected cells. Animal studies demonstrate that secretin receptor deficiency slightly, but significantly, prolongs incubation time in female but not male mice. This gender-specificity is consistent with our finding that prion-infected cells are derived from females. Therefore, our results provide initial insights into the reasons why age of disease onset in certain prion diseases is reported to occur slightly earlier in females than males.

Original languageEnglish
Article number37195
Pages (from-to)2011-2018
Number of pages8
JournalFEBS Letters
Volume589
Issue number15
DOIs
Publication statusPublished - 2015 Jul 3

Keywords

  • Gender effect
  • Incubation time
  • Knockout mouse
  • N2a cells
  • Prion
  • Secretin receptor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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