Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior

Ichiko Nishijima, Takanori Yamagata, Corinne M. Spencer, Edwin J. Weeber, Olga Alekseyenko, J. David Sweatt, Mariko Y. Momoi, Masayuki Ito, Dawna L. Armstrong, David L. Nelson, Richard Paylor, Allan Bradley

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Secretin is a peptide hormone released from the duodenum to stimulate the secretion of digestive juice by the pancreas. Secretin also functions as a neuropeptide hormone in the brain, and exogenous administration has been reported to alleviate symptoms in some patients with autism. We have generated secretin receptor-deficient mice to explore the relationship between secretin signaling in the brain and behavioral phenotypes. Secretin receptor-deficient mice are overtly normal and fertile; however, synaptic plasticity in the hippocampus is impaired and there are slightly fewer dendritic spines in the CA1 hippocampal pyramidal cells. Furthermore, secretin receptor-deficient mice show abnormal social and cognitive behaviors. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior.

Original languageEnglish
Pages (from-to)3241-3250
Number of pages10
JournalHuman molecular genetics
Volume15
Issue number21
DOIs
Publication statusPublished - 2006 Nov 1
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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