Secondary osteosarcoma arising after treatment for childhood hematologic malignancies

Atsushi Okada, Masahito Hatori, Masami Hosaka, Munenori Watanuki, Eiji Itoi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Secondary osteosarcoma arising after the treatment of hematologic malignancies other than Hodgkin's lymphoma is rare. We report two cases of secondary osteosarcoma arising after treatment for childhood hematologic malignancies (non-Hodgkin's lymphoma and lymphoblastic leukemia). A 10-year-old boy, at the age of 3, was diagnosed with non-Hodgkin's lymphoma. He received chemotherapy, radiation, and bone-marrow transplantation and then was in complete remission. At 6 years, he complained of increasing pain of the right thigh and was diagnosed with osteoblastic osteosarcoma. A 26-year-old man, at the age of 6, was diagnosed as having acute lymphoblastic leukemia (ALL). He received chemotherapy, radiation, and peripheral blood stem cell transplantation (PBSCT). At 11 years after PBSCT, he visited with the complaint of left lumbar swelling. He was diagnosed with chondroblastic osteosarcoma. In both cases alkaline phosphatase (ALP) had already increased prior to the onset of the symptom. We should rule out secondary osteosarcoma at the abnormal elevation of ALP during clinical follow-up of patients after treatment of childhood hematologic malignancies.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalUpsala Journal of Medical Sciences
Volume114
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • Acute lymphoblastic leukemia
  • Non-Hodgkin's lymphoma
  • Osteosarcoma
  • Secondary cancer

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Secondary osteosarcoma arising after treatment for childhood hematologic malignancies'. Together they form a unique fingerprint.

Cite this