Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae)

Ghislain Wabo Fotso, Justin Kamga, Bathelemy Ngameni, Shota Uesugi, Misa Ohno, Ken Ichi Kimura, Hiroyuki Momma, Eunsang Kwon, Hiroshi Furuno, Yoshihito Shiono, Simo K. Ingrid, Samuel O. Yeboah, Bonaventure T. Ngadjui

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5 Citations (Scopus)

Abstract

A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3′,4′, 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) and chondrillasterone (6), and a triterpenoid: lupeol (7). The structure of 1 was established by detailed analysis of its spectroscopic data, especially 1D and 2D NMR spectra, HRESIMS and CD data. Compounds 1–6 were assayed for their antiproliferative effects on two human cancer cells, HeLa at 50 μM (n = 2) and HL60 at 20 μM (n = 2). Compound 3 and 4 were the most active on HL60 with IC50 of 8.1 and 8.3 μM, respectively. Compound 6 was the most active with an IC50 of 4.6 μM on HeLa.

Original languageEnglish
Pages (from-to)1981-1987
Number of pages7
JournalNatural Product Research
Volume31
Issue number17
DOIs
Publication statusPublished - 2017 Jan 1

Keywords

  • Albizia glaberrimavar glabrescens Oliv
  • Albiziaflavan B
  • antiproliferative effects
  • butin
  • chondrillasterone
  • fustin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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  • Cite this

    Fotso, G. W., Kamga, J., Ngameni, B., Uesugi, S., Ohno, M., Kimura, K. I., Momma, H., Kwon, E., Furuno, H., Shiono, Y., Ingrid, S. K., Yeboah, S. O., & Ngadjui, B. T. (2017). Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae). Natural Product Research, 31(17), 1981-1987. https://doi.org/10.1080/14786419.2016.1269097