Second lung adenocarcinoma after combination chemotherapy in two patients with primary non-Hodgkin's lymphoma

Tetsuya Yamada, Kenji Shinohara, Koumei Takeda, Naoko Kameda, Kensaku Katsuki, Kouichi Ariyoshi, Toshiaki Kamei

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10 Citations (Scopus)

Abstract

We report a rare complication of a secondary malignant solid tumor in two patients with non-Hodgkin's malignant lymphoma who developed lung adenocarcinoma after treatments with combination chemotherapies. The first was a case of primary malignant lymphoma of the cervical spinal cord which had been previously treated with radiation to the spinal lesion and combination chemotherapies and entered complete remission. The patient was further treated for relapse with autologous bone marrow transplantation preconditioned with high-dose chemotherapy. Lung adenocarcinoma developed 5.5 years after the initial diagnosis. The second case of malignant lymphoma of lymph nodes did not respond to conventional combination chemotherapies and did not enter remission. Lung adenocarcinoma developed 1 year after the initial diagnosis. The two patients died of lung carcinoma. The clinical profiles of these cases are presented and the causal relationship of primary malignant neoplasms to the second malignant neoplasms is discussed.

Original languageEnglish
Pages (from-to)226-228
Number of pages3
JournalJapanese journal of clinical oncology
Volume29
Issue number4
DOIs
Publication statusPublished - 1999 Apr

Keywords

  • Combination chemotherapy
  • Lung adenocarcinoma
  • Malignant lymphoma
  • Second malignant neoplasm

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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