Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody

Tetsuya Akaishi, Juichi Fujimori, Toshiyuki Takahashi, Tatsuro Misu, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Ryo Ogawa, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Ichiro Nakashima

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) showed spring–summer predominance of the clinical onset. Conversely, patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease showed autumn–winter predominance of the clinical onset. Both seasonal variations were irrespective of the clinical manifestation. Environmental factors with seasonal variation influence the development of neurological conditions related to AQP4-IgG and MOG-IgG.

Original languageEnglish
Article number577431
JournalJournal of Neuroimmunology
Volume349
DOIs
Publication statusPublished - 2020 Dec 15

Keywords

  • Aquapotin-4
  • Attacks
  • Myelin-oligodendrocyte glycoprotein
  • Neuromyelitis optica spectrum disorders
  • Seasonal distribution

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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