Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody

Tetsuya Akaishi; Juichi Fujimori; Toshiyuki Takahashi; Tatsuro Misu; Yoshiki Takai; Shuhei Nishiyama; Kimihiko Kaneko; Ryo Ogawa; Michiaki Abe; Tadashi Ishii; Masashi Aoki; Kazuo Fujihara; Ichiro Nakashima

doi:10.1016/j.jneuroim.2020.577431

Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody

Tetsuya Akaishi, Juichi Fujimori, Toshiyuki Takahashi, Tatsuro Misu, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Ryo Ogawa, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Ichiro Nakashima

Research output: Contribution to journal › Article › peer-review

Abstract

This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) showed spring–summer predominance of the clinical onset. Conversely, patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease showed autumn–winter predominance of the clinical onset. Both seasonal variations were irrespective of the clinical manifestation. Environmental factors with seasonal variation influence the development of neurological conditions related to AQP4-IgG and MOG-IgG.

Original language	English
Article number	577431
Journal	Journal of Neuroimmunology
Volume	349
DOIs	https://doi.org/10.1016/j.jneuroim.2020.577431
Publication status	Published - 2020 Dec 15

Keywords

Aquapotin-4
Attacks
Myelin-oligodendrocyte glycoprotein
Neuromyelitis optica spectrum disorders
Seasonal distribution

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/j.jneuroim.2020.577431

Fingerprint Dive into the research topics of 'Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody'. Together they form a unique fingerprint.

Cite this

Akaishi, T., Fujimori, J., Takahashi, T., Misu, T., Takai, Y., Nishiyama, S., Kaneko, K., Ogawa, R., Abe, M., Ishii, T., Aoki, M., Fujihara, K., & Nakashima, I. (2020). Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody. Journal of Neuroimmunology, 349, [577431]. https://doi.org/10.1016/j.jneuroim.2020.577431

Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody. / Akaishi, Tetsuya; Fujimori, Juichi; Takahashi, Toshiyuki; Misu, Tatsuro ; Takai, Yoshiki ; Nishiyama, Shuhei; Kaneko, Kimihiko; Ogawa, Ryo; Abe, Michiaki ; Ishii, Tadashi ; Aoki, Masashi; Fujihara, Kazuo; Nakashima, Ichiro.

In: Journal of Neuroimmunology, Vol. 349, 577431, 15.12.2020.

Research output: Contribution to journal › Article › peer-review

Akaishi, T, Fujimori, J, Takahashi, T, Misu, T , Takai, Y , Nishiyama, S, Kaneko, K, Ogawa, R, Abe, M , Ishii, T , Aoki, M, Fujihara, K & Nakashima, I 2020, 'Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody', Journal of Neuroimmunology, vol. 349, 577431. https://doi.org/10.1016/j.jneuroim.2020.577431

Akaishi, Tetsuya ; Fujimori, Juichi ; Takahashi, Toshiyuki ; Misu, Tatsuro ; Takai, Yoshiki ; Nishiyama, Shuhei ; Kaneko, Kimihiko ; Ogawa, Ryo ; Abe, Michiaki ; Ishii, Tadashi ; Aoki, Masashi ; Fujihara, Kazuo ; Nakashima, Ichiro. / Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody. In: Journal of Neuroimmunology. 2020 ; Vol. 349.

@article{cedb4e656d8d4550bf96502526917cca,

title = "Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody",

abstract = "This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) showed spring–summer predominance of the clinical onset. Conversely, patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease showed autumn–winter predominance of the clinical onset. Both seasonal variations were irrespective of the clinical manifestation. Environmental factors with seasonal variation influence the development of neurological conditions related to AQP4-IgG and MOG-IgG.",

keywords = "Aquapotin-4, Attacks, Myelin-oligodendrocyte glycoprotein, Neuromyelitis optica spectrum disorders, Seasonal distribution",

author = "Tetsuya Akaishi and Juichi Fujimori and Toshiyuki Takahashi and Tatsuro Misu and Yoshiki Takai and Shuhei Nishiyama and Kimihiko Kaneko and Ryo Ogawa and Michiaki Abe and Tadashi Ishii and Masashi Aoki and Kazuo Fujihara and Ichiro Nakashima",

note = "Funding Information: We deeply thank Ms. Chisato Wakabayashi and Ms. Haruka Chounan (Tohoku Medical and Pharmaceutical University, Japan) for collecting and purifying the data used in this study.",

year = "2020",

month = dec,

day = "15",

doi = "10.1016/j.jneuroim.2020.577431",

language = "English",

volume = "349",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

}

TY - JOUR

T1 - Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody

AU - Akaishi, Tetsuya

AU - Fujimori, Juichi

AU - Takahashi, Toshiyuki

AU - Misu, Tatsuro

AU - Takai, Yoshiki

AU - Nishiyama, Shuhei

AU - Kaneko, Kimihiko

AU - Ogawa, Ryo

AU - Abe, Michiaki

AU - Ishii, Tadashi

AU - Aoki, Masashi

AU - Fujihara, Kazuo

AU - Nakashima, Ichiro

N1 - Funding Information: We deeply thank Ms. Chisato Wakabayashi and Ms. Haruka Chounan (Tohoku Medical and Pharmaceutical University, Japan) for collecting and purifying the data used in this study.

PY - 2020/12/15

Y1 - 2020/12/15

N2 - This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) showed spring–summer predominance of the clinical onset. Conversely, patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease showed autumn–winter predominance of the clinical onset. Both seasonal variations were irrespective of the clinical manifestation. Environmental factors with seasonal variation influence the development of neurological conditions related to AQP4-IgG and MOG-IgG.

AB - This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) showed spring–summer predominance of the clinical onset. Conversely, patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease showed autumn–winter predominance of the clinical onset. Both seasonal variations were irrespective of the clinical manifestation. Environmental factors with seasonal variation influence the development of neurological conditions related to AQP4-IgG and MOG-IgG.

KW - Aquapotin-4

KW - Attacks

KW - Myelin-oligodendrocyte glycoprotein

KW - Neuromyelitis optica spectrum disorders

KW - Seasonal distribution

UR - http://www.scopus.com/inward/record.url?scp=85096114262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85096114262&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2020.577431

DO - 10.1016/j.jneuroim.2020.577431

M3 - Article

C2 - 33147540

AN - SCOPUS:85096114262

VL - 349

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

M1 - 577431

ER -