TY - JOUR
T1 - Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody
AU - Akaishi, Tetsuya
AU - Fujimori, Juichi
AU - Takahashi, Toshiyuki
AU - Misu, Tatsuro
AU - Takai, Yoshiki
AU - Nishiyama, Shuhei
AU - Kaneko, Kimihiko
AU - Ogawa, Ryo
AU - Abe, Michiaki
AU - Ishii, Tadashi
AU - Aoki, Masashi
AU - Fujihara, Kazuo
AU - Nakashima, Ichiro
N1 - Funding Information:
We deeply thank Ms. Chisato Wakabayashi and Ms. Haruka Chounan (Tohoku Medical and Pharmaceutical University, Japan) for collecting and purifying the data used in this study.
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/12/15
Y1 - 2020/12/15
N2 - This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) showed spring–summer predominance of the clinical onset. Conversely, patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease showed autumn–winter predominance of the clinical onset. Both seasonal variations were irrespective of the clinical manifestation. Environmental factors with seasonal variation influence the development of neurological conditions related to AQP4-IgG and MOG-IgG.
AB - This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) showed spring–summer predominance of the clinical onset. Conversely, patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease showed autumn–winter predominance of the clinical onset. Both seasonal variations were irrespective of the clinical manifestation. Environmental factors with seasonal variation influence the development of neurological conditions related to AQP4-IgG and MOG-IgG.
KW - Aquapotin-4
KW - Attacks
KW - Myelin-oligodendrocyte glycoprotein
KW - Neuromyelitis optica spectrum disorders
KW - Seasonal distribution
UR - http://www.scopus.com/inward/record.url?scp=85096114262&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85096114262&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2020.577431
DO - 10.1016/j.jneuroim.2020.577431
M3 - Article
C2 - 33147540
AN - SCOPUS:85096114262
VL - 349
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
SN - 0165-5728
M1 - 577431
ER -