Seasonal and activity-dependent variations of piperidine levels in the amphibian brain

Takeshi Miyata, Yoshiro Okano, Koji Fukunaga, Kazuo Takahama, Yoshitoshi Kasé

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Piperidine is one of biogenic amines possessing nicotine-like synaptotropic actions on the nervous systems. Since piperidine produces multiplex physiological actions, a role for the amine as a modulator in neuroendocrine as well as neuronal functions has been supposed. In the present study, piperidine levels in the amphibian brains during activity and hibernation were examined by use of a mass fragmentographic technique and it was found that the brain piperidine concentrations significantly increased in the cold season especially during hibernation. The significance of the findings is discussed with respect to the hypnogenic effect of piperidine.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalBrain research
Issue number1
Publication statusPublished - 1980 Sep 15
Externally publishedYes


  • dormancy
  • hibernation
  • mass fragmentography
  • piperidine
  • seasonal and activity-dependent variations

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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