Screening of chemical compound libraries identified new anti-Toxoplasma gondii agents

Oluyomi Stephen Adeyemi, Tatsuki Sugi, Yongmei Han, Kentaro Kato

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Toxoplasma gondii is the etiological agent of toxoplasmosis, a common parasitic disease that affects nearly one-third of the human population. The primary infection can be asymptomatic in healthy individuals but may prove fatal in immunocompromised individuals. Available treatment options for toxoplasmosis patients are limited, underscoring the urgent need to identify and develop new therapies. Non-biased screening of libraries of chemical compounds including the repurposing of well-characterized compounds is emerging as viable approach to achieving this goal. In the present investigation, we screened libraries of natural product and FDA-approved compounds to identify those that inhibited T. gondii growth. We identified 32 new compounds that potently inhibit T. gondii growth. Our findings are new and promising, and further strengthen the prospects of drug repurposing as well as the screening of a wide range of chemical compounds as a viable source of alternative anti-parasitic therapeutic agents.

Original languageEnglish
Pages (from-to)355-363
Number of pages9
JournalParasitology Research
Volume117
Issue number2
DOIs
Publication statusPublished - 2018 Feb 1
Externally publishedYes

Keywords

  • Anti-parasitic
  • Drug discovery
  • FDA-approved compounds
  • Natural products
  • Toxoplasmosis

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)
  • Insect Science
  • Infectious Diseases

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