Alloy 182-Low Alloy Steel (LAS) dissimilar weld joints contain the transition region that has complex microstructure. Recent incidents of stress corrosion cracking (SCC) in the weld metal of bottom head penetration housing of Boiling Water Reactors (BWR) have drawn the attention to the SCC behavior in the transition region of Alloy 182-LAS dissimilar weld joints, and in particular, to the issue whether an intergranular/interdendritic SCC crack propagating in the weld metal could easily penetrate through the fusion line into the adjacent LAS. In this study, following a microstructural characterization of the transition region of an Alloy 182-SA 508 C1.2 dissimilar weld joint, the SCC behavior in the transition region in simulated BWR-Normal Water Chemistry (NWC) environments was investigated. The results showed that the microstructure had a sharp change across the fusion line, and that the SCC propagation tended to cease at the fusion line under near-constant loading conditions. Such a SCC behavior shows consistency with the well-known SCC behavior of LAS, and with the field experience where SCC is usually confined to the Alloy 182 weld metal.