TY - JOUR
T1 - Scabronines B, C, D, E and F, novel diterpenoids showing stimulating activity of nerve growth factor-synthesis, from the mushroom Sarcodon scabrosus
AU - Kita, Takako
AU - Takaya, Yoshiaki
AU - Oshima, Yoshiteru
AU - Ohta, Tomihisa
AU - Aizawa, Koichi
AU - Hirano, Takaaki
AU - Inakuma, Takahiro
PY - 1998/9/24
Y1 - 1998/9/24
N2 - Novel cyathane-type diterpenoids, scabronines B - F (1 - 5) were isolated from the mushroom Sarcodon scabrosus. Their structures were determined by interpretation of their spectral data and chemical transformation. The absolute stereochemistry of scabronine C (2) was confirmed by the exciton chirality method, and the chemical transformation of scabronines B, C and D (1, 2 and 3) clarified their absolute structures. The absolute stereochemistries of scabronines E and F (4 and 5) were determined by comparison of their CD spectra with that of erinacine A (7). Among these compounds, scabronines B, C and E (1, 2 and 4) exhibit stimulating activity of the synthesis of a nerve growth factor.
AB - Novel cyathane-type diterpenoids, scabronines B - F (1 - 5) were isolated from the mushroom Sarcodon scabrosus. Their structures were determined by interpretation of their spectral data and chemical transformation. The absolute stereochemistry of scabronine C (2) was confirmed by the exciton chirality method, and the chemical transformation of scabronines B, C and D (1, 2 and 3) clarified their absolute structures. The absolute stereochemistries of scabronines E and F (4 and 5) were determined by comparison of their CD spectra with that of erinacine A (7). Among these compounds, scabronines B, C and E (1, 2 and 4) exhibit stimulating activity of the synthesis of a nerve growth factor.
KW - Diterpenoids
KW - Fungi
KW - Nerve growth factor synthesis
UR - http://www.scopus.com/inward/record.url?scp=0032563997&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032563997&partnerID=8YFLogxK
U2 - 10.1016/S0040-4020(98)83045-7
DO - 10.1016/S0040-4020(98)83045-7
M3 - Article
AN - SCOPUS:0032563997
VL - 54
SP - 11877
EP - 11886
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 39
ER -