Scabronine A, a novel diterpenoid having potent inductive activity of the nerve growth factor synthesis, isolated from the mushroom, Sarcodon scabrosus

Tomihisa Ohta, Takako Kita, Norihiro Kobayashi, Yutaro Obara, Norimichi Nakahata, Yasushi Ohizumi, Yoshiaki Takaya, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

A novel diterpenoid, scabronine A, having strong inductive activity of the nerve growth factor synthesis was isolated from the fruit body of the mushroom, Sarcodon scabrosus (Fr.) Karst. The stereostructure of scabronine A (1) was elucidated on the basis of the spectroscopic analysis of natural scabronine A and its derivatives.

Original languageEnglish
Pages (from-to)6229-6232
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number34
DOIs
Publication statusPublished - 1998 Aug 20

Keywords

  • Carboxylic acids and derivatives
  • Fungi
  • Stereochemistry
  • Terpenes and terpenoids

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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