Scabronine A, a novel diterpenoid having potent inductive activity of the nerve growth factor synthesis, isolated from the mushroom, Sarcodon scabrosus

Tomihisa Ohta; Takako Kita; Norihiro Kobayashi; Yutaro Obara; Norimichi Nakahata; Yasushi Ohizumi; Yoshiaki Takaya; Yoshiteru Oshima

doi:10.1016/S0040-4039(98)01282-9

Scabronine A, a novel diterpenoid having potent inductive activity of the nerve growth factor synthesis, isolated from the mushroom, Sarcodon scabrosus

Tomihisa Ohta, Takako Kita, Norihiro Kobayashi, Yutaro Obara, Norimichi Nakahata, Yasushi Ohizumi, Yoshiaki Takaya, Yoshiteru Oshima

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

A novel diterpenoid, scabronine A, having strong inductive activity of the nerve growth factor synthesis was isolated from the fruit body of the mushroom, Sarcodon scabrosus (Fr.) Karst. The stereostructure of scabronine A (1) was elucidated on the basis of the spectroscopic analysis of natural scabronine A and its derivatives.

Original language	English
Pages (from-to)	6229-6232
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	34
DOIs	https://doi.org/10.1016/S0040-4039(98)01282-9
Publication status	Published - 1998 Aug 20

Keywords

Carboxylic acids and derivatives
Fungi
Stereochemistry
Terpenes and terpenoids

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(98)01282-9

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abstract = "A novel diterpenoid, scabronine A, having strong inductive activity of the nerve growth factor synthesis was isolated from the fruit body of the mushroom, Sarcodon scabrosus (Fr.) Karst. The stereostructure of scabronine A (1) was elucidated on the basis of the spectroscopic analysis of natural scabronine A and its derivatives.",

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author = "Tomihisa Ohta and Takako Kita and Norihiro Kobayashi and Yutaro Obara and Norimichi Nakahata and Yasushi Ohizumi and Yoshiaki Takaya and Yoshiteru Oshima",

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T1 - Scabronine A, a novel diterpenoid having potent inductive activity of the nerve growth factor synthesis, isolated from the mushroom, Sarcodon scabrosus

AU - Ohta, Tomihisa

AU - Kita, Takako

AU - Kobayashi, Norihiro

AU - Obara, Yutaro

AU - Nakahata, Norimichi

AU - Ohizumi, Yasushi

AU - Takaya, Yoshiaki

AU - Oshima, Yoshiteru

PY - 1998/8/20

Y1 - 1998/8/20

N2 - A novel diterpenoid, scabronine A, having strong inductive activity of the nerve growth factor synthesis was isolated from the fruit body of the mushroom, Sarcodon scabrosus (Fr.) Karst. The stereostructure of scabronine A (1) was elucidated on the basis of the spectroscopic analysis of natural scabronine A and its derivatives.

AB - A novel diterpenoid, scabronine A, having strong inductive activity of the nerve growth factor synthesis was isolated from the fruit body of the mushroom, Sarcodon scabrosus (Fr.) Karst. The stereostructure of scabronine A (1) was elucidated on the basis of the spectroscopic analysis of natural scabronine A and its derivatives.

KW - Carboxylic acids and derivatives

KW - Fungi

KW - Stereochemistry

KW - Terpenes and terpenoids

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VL - 39

SP - 6229

EP - 6232

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 34

ER -

Scabronine A, a novel diterpenoid having potent inductive activity of the nerve growth factor synthesis, isolated from the mushroom, Sarcodon scabrosus

Abstract

Keywords

ASJC Scopus subject areas

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