Sarcoma-like tumor originating from oligodendroglioma

Takuhiro Shoji, Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We present a case of sarcoma occurring at a site of resected oligodendroglioma without preceding radiotherapy or chemotherapy. Oligosarcoma occurring at sites of resected oligodendroglioma or anaplastic oligodendroglioma with sarcomatous components are rare. Although meningioma or sarcoma-like lesions are sometimes reported after glioma-targeted radiotherapy, those without preceding radiotherapy are quite rare. Moreover, cases of sarcoma without oligodendroglial components occurring at a site of resected oligodendroglioma have never been reported. In this case, fluorescent in situ hybridization analysis revealed 1p/19q co-deletion in both the first tumor and second tumors. Additionally, immunohistochemistry revealed mutated isocitrate dehydrogenase 1 in both tumors. Taken together, these findings suggest a monoclonal tumor origin. Consequently, this case may indicate a new mechanism of development of sarcomatous lesions occurring at the site of a resected glioma.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalBrain Tumor Pathology
Volume33
Issue number4
DOIs
Publication statusPublished - 2016 Oct 1

Keywords

  • 1p/19q co-deletion
  • Fluorescent in situ hybridization
  • Isocitrate dehydrogenase-1
  • Oligodendroglioma
  • Sarcoma

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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