Salvage chemotherapy with docetaxel, ifosfamide and nedaplatin (DIN) for patients with advanced germ cell tumors: A preliminary report

Shigeyuki Yamada, Hideo Saito, Shinya Ohara, Shinichi Yamashita, Koji Mitsuzuka, Shunichi Namiki, Minoru Miyazato, Yasuhiro Kaiho, Akihiro Ito, Haruo Nakagawa, Shigeto Ishidoya, Yoichi Arai

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Objective: We investigated the efficacy and toxicity of a docetaxel, ifosfamide and nedaplatin regimen as salvage therapy for patients with advanced testicular germ cell tumor. Methods: Eleven patients with advanced germ cell tumor refractory or relapsed after cisplatinbased chemotherapy were treated using docetaxel, ifosfamide and nedaplatin. The docetaxel, ifosfamide and nedaplatin regimen comprised docetaxel (75 mg/m2) on Day 1, ifosfamide (2 g/ m2) on Days 1-3 and nedaplatin (75 mg/m2) on Day 2 of a 3-week cycle. Results: Ten (91%) of the 11 patients achieved favorable responses, including complete response in one case and partial response in nine cases. Nine (81%) of the 11 patients have continued to show no evidence of disease after docetaxel, ifosfamide and nedaplatin therapy followed by subsequent surgical resection, with a median follow-up period of 52 months. One patient died of the disease 3 months after completing docetaxel, ifosfamide and nedaplatin chemotherapy. One patient was lost to follow-up with a status of alive with disease. Ten (91%) of the 11 patients developed Grade 4 leukopenia, which was managed using granulocyte colony-stimulating factor. No patients developed sensory neuropathy or renal dysfunction. Conclusions: The docetaxel, ifosfamide and nedaplatin regimen was efficacious and welltolerated as salvage chemotherapy for patients with advanced germ cell tumor.

Original languageEnglish
Pages (from-to)734-739
Number of pages6
JournalJapanese journal of clinical oncology
Volume43
Issue number7
DOIs
Publication statusPublished - 2013 Jul

Keywords

  • Docetaxel
  • Germ cell tumor
  • Ifosfamide
  • Nedaplatin
  • Salvage chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint Dive into the research topics of 'Salvage chemotherapy with docetaxel, ifosfamide and nedaplatin (DIN) for patients with advanced germ cell tumors: A preliminary report'. Together they form a unique fingerprint.

Cite this