Salt loading reduces hypothalamic noradrenaline release after noxious stimuli

Yuki Takayanagi, Katsuhiko Nishimori, Tatsushi Onaka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Salt loading reduces neuroendocrine responses to stressful stimuli. Noxious stimuli facilitate noradrenaline release in the hypothalamus and, as a result, activate oxytocin neurones. Here, we examined effects of salt loading upon plasma oxytocin concentrations and noradrenaline release in the hypothalamus after footshocks. Male rats were allowed to drink 2% NaCl for 7 days. Salt loading reduced the footshock-induced increase in plasma oxytocin concentrations and noradrenaline release in the supraoptic nucleus (SON). Acute administration of hypertonic saline also attenuated the footshock-induced noradrenaline increase in the supraoptic nucleus. In contrast, salt loading did not significantly change activation of A1 catecholaminergic neurones in the medulla oblongata, as measured by expression of Fos protein. These data suggest that salt loading presynaptically suppresses noradrenaline release in the hypothalamus and oxytocin release into the blood after footshocks.

Original languageEnglish
Pages (from-to)22-27
Number of pages6
JournalNeuroscience Letters
Volume391
Issue number1-2
DOIs
Publication statusPublished - 2005 Dec 31

Keywords

  • Noradrenaline
  • Oxytocin
  • Salt loading
  • Stress
  • Supraoptic nucleus
  • Vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)

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