Background: Salt-inducible kinases (SIKs) are capable of suppressing gluconeogenic gene expression in hepatocytes when they are overexpressed. Results: However, enhanced gluconeogenic programs are observed only in SIK3-defective hepatocytes. Conclusion: SIK3 is the major kinase that down-regulates gluconeogenesis. Significance: The present study proposes that SIK3 could be a new target of diabetic care.
|Number of pages||15|
|Journal||Journal of Biological Chemistry|
|Publication status||Published - 2015 Jul 17|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology