Salt-inducible kinase 3 signaling is important for the gluconeogenic programs in mouse hepatocytes

Yumi Itoh; Masato Sanosaka; Hiroyuki Fuchino; Yasuhito Yahara; Ayako Kumagai; Daisaku Takemoto; Mai Kagawa; Junko Doi; Miho Ohta; Noriyuki Tsumaki; Nobuo Kawahara; Hiroshi Takemori

doi:10.1074/jbc.M115.640821

Salt-inducible kinase 3 signaling is important for the gluconeogenic programs in mouse hepatocytes

Yumi Itoh, Masato Sanosaka, Hiroyuki Fuchino, Yasuhito Yahara, Ayako Kumagai, Daisaku Takemoto, Mai Kagawa, Junko Doi, Miho Ohta, Noriyuki Tsumaki, Nobuo Kawahara, Hiroshi Takemori

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Background: Salt-inducible kinases (SIKs) are capable of suppressing gluconeogenic gene expression in hepatocytes when they are overexpressed. Results: However, enhanced gluconeogenic programs are observed only in SIK3-defective hepatocytes. Conclusion: SIK3 is the major kinase that down-regulates gluconeogenesis. Significance: The present study proposes that SIK3 could be a new target of diabetic care.

Original language	English
Pages (from-to)	17879-17893
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	290
Issue number	29
DOIs	https://doi.org/10.1074/jbc.M115.640821
Publication status	Published - 2015 Jul 17
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M115.640821

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title = "Salt-inducible kinase 3 signaling is important for the gluconeogenic programs in mouse hepatocytes",

abstract = "Background: Salt-inducible kinases (SIKs) are capable of suppressing gluconeogenic gene expression in hepatocytes when they are overexpressed. Results: However, enhanced gluconeogenic programs are observed only in SIK3-defective hepatocytes. Conclusion: SIK3 is the major kinase that down-regulates gluconeogenesis. Significance: The present study proposes that SIK3 could be a new target of diabetic care.",

author = "Yumi Itoh and Masato Sanosaka and Hiroyuki Fuchino and Yasuhito Yahara and Ayako Kumagai and Daisaku Takemoto and Mai Kagawa and Junko Doi and Miho Ohta and Noriyuki Tsumaki and Nobuo Kawahara and Hiroshi Takemori",

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doi = "10.1074/jbc.M115.640821",

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T1 - Salt-inducible kinase 3 signaling is important for the gluconeogenic programs in mouse hepatocytes

AU - Itoh, Yumi

AU - Sanosaka, Masato

AU - Fuchino, Hiroyuki

AU - Yahara, Yasuhito

AU - Kumagai, Ayako

AU - Takemoto, Daisaku

AU - Kagawa, Mai

AU - Doi, Junko

AU - Ohta, Miho

AU - Tsumaki, Noriyuki

AU - Kawahara, Nobuo

AU - Takemori, Hiroshi

PY - 2015/7/17

Y1 - 2015/7/17

N2 - Background: Salt-inducible kinases (SIKs) are capable of suppressing gluconeogenic gene expression in hepatocytes when they are overexpressed. Results: However, enhanced gluconeogenic programs are observed only in SIK3-defective hepatocytes. Conclusion: SIK3 is the major kinase that down-regulates gluconeogenesis. Significance: The present study proposes that SIK3 could be a new target of diabetic care.

AB - Background: Salt-inducible kinases (SIKs) are capable of suppressing gluconeogenic gene expression in hepatocytes when they are overexpressed. Results: However, enhanced gluconeogenic programs are observed only in SIK3-defective hepatocytes. Conclusion: SIK3 is the major kinase that down-regulates gluconeogenesis. Significance: The present study proposes that SIK3 could be a new target of diabetic care.

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Salt-inducible kinase 3 signaling is important for the gluconeogenic programs in mouse hepatocytes

Abstract

ASJC Scopus subject areas

UN SDGs

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