Salt-inducible kinase 3 signaling is important for the gluconeogenic programs in mouse hepatocytes

Yumi Itoh, Masato Sanosaka, Hiroyuki Fuchino, Yasuhito Yahara, Ayako Kumagai, Daisaku Takemoto, Mai Kagawa, Junko Doi, Miho Ohta, Noriyuki Tsumaki, Nobuo Kawahara, Hiroshi Takemori

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Background: Salt-inducible kinases (SIKs) are capable of suppressing gluconeogenic gene expression in hepatocytes when they are overexpressed. Results: However, enhanced gluconeogenic programs are observed only in SIK3-defective hepatocytes. Conclusion: SIK3 is the major kinase that down-regulates gluconeogenesis. Significance: The present study proposes that SIK3 could be a new target of diabetic care.

Original languageEnglish
Pages (from-to)17879-17893
Number of pages15
JournalJournal of Biological Chemistry
Volume290
Issue number29
DOIs
Publication statusPublished - 2015 Jul 17

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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