Salivary levels of cortisol and chromogranin A in patients with dry mouth compared with age-matched controls

Chieko Shigeyama, Toshihiro Ansai, Shuji Awano, Inho Soh, Akihiro Yoshida, Tomoko Hamasaki, Yasuaki Kakinoki, Kazuhiro Tominaga, Tetsu Takahashi, Tadamichi Takehara

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Objective: To evaluate the salivary levels of cortisol and chromogranin A (CgA) in patients with dry mouth (perceived xerostomia and hyposalivation) compared with age-matched controls. Study design: We studied 174 subjects, including those with dry mouth, classified into 2 subgroups based on perceived xerostomia and salivation, and those without (control subjects). The control subjects were patients at the same hospital and healthy volunteers. Cortisol and CgA levels in stimulated whole saliva were measured using ELISA kits. Results: All subjects with dry mouth had significantly higher cortisol and CgA levels than the control subjects. The statistical associations remained significant when they were divided into the 2 subgroups, although somewhat weaker associations were observed. The influences of xerogenic drugs were found to be minimal on salivary flow rate and levels of cortisol and CgA. Conclusions: We found significant associations between salivary cortisol and CgA levels and symptoms of oral dryness and reduced salivary flow.

Original languageEnglish
Pages (from-to)833-839
Number of pages7
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Volume106
Issue number6
DOIs
Publication statusPublished - 2008 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

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