Safety and efficacy of fibrinolytic agents in acute ischemic stroke

Etsuro Mori

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The modem concepts of recanalization strategies by using fibrinolytic agents are discussed. Therapeutic thrombolysis in cerebral ischemia has entailed the use of streptokinase, urokinase, and recombinant tissue plasminogen activator by either systemic or intra-arterial infusion. At the present time, experience suggests that early recanalization is followed by neurological improvement, and use of thrombolytic agents does not increase the incidence of hemorrhagic transformation. In addition, studies of repeated intravenous administration of low-dose thrombolytic agents, another mode of thrombolytic agent usage, which have been conducted uniquely in Japan, are critically reviewed, and the role for treating ischemic stroke is discussed.

Original languageEnglish
Pages (from-to)264-268
Number of pages5
JournalCerebrovascular Diseases
Issue number4
Publication statusPublished - 1993


  • Clinical trial
  • Ischemic stroke
  • Thrombolytic therapy
  • Tissue plasminogen activator
  • Urokinase

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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