Ruthenium-catalyzed arylation of 2-alkenylpyridines with aryl bromides: Alternative E,Z-selectivity to Mizoroki-Heck reaction

Shuichi Oi, Kaori Sakai, Yoshio Inoue

Research output: Contribution to journalArticlepeer-review

98 Citations (Scopus)

Abstract

(Chemical Equation Presented) Regio- and stereoselective arylation of 2-alkenylpyridines with aryl bromides is catalyzed by specific Ru(II)-phosphine complexes affording β-arylated (Z)-2-alkenylpyridines, in which the aryl moiety is introduced cis to the pyridyl group. This geometrical selectivity is in sharp contrast to the Mizoroki-Heck reaction.

Original languageEnglish
Pages (from-to)4009-4011
Number of pages3
JournalOrganic letters
Volume7
Issue number18
DOIs
Publication statusPublished - 2005 Sep 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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