Runx3 deficiency results in myeloproliferative disorder in aged mice

Chelsia Qiuxia Wang, Lena Motoda, Masanobu Satake, Yoshiaki Ito, Ichiro Taniuchi, Vinay Tergaonkar, Motomi Osato

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


The RUNX family genes encode transcription factors that are involved in development and human diseases. RUNX1 is one of the most frequently mutated genes in human hematological malignancies and is a critical factor for the generation and maintenance of hematopoietic stem cells. Another Runx family gene, Runx3, is known to be expressed in hematopoietic cells. However, its involvement in hematopoiesis remains unclear. Here we show the hematopoietic phenotypes in Runx3 conditional knockout (KO) mice (Runx3fl/fl; Mx1-Cre+): whereas young Runx3 KO mice did not exhibit any significant hematopoietic defects, aged Runx3 KO mice developed a myeloproliferative disorder characterized by myeloid-dominant leukocytosis, splenomegaly, and an increase of hematopoietic stem/ progenitor cells (HSPCs). Notably, Runx3-deficient cells showed hypersensitivity to granulocyte-colony stimulating factor, suggesting enhanced proliferative and mobilization capability of Runx3-deficient HSPCs when stimulated. These results suggest that, besides Runx1, Runx3 also plays a role in hematopoiesis.

Original languageEnglish
Pages (from-to)562-566
Number of pages5
Issue number4
Publication statusPublished - 2013 Jul 25
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


Dive into the research topics of 'Runx3 deficiency results in myeloproliferative disorder in aged mice'. Together they form a unique fingerprint.

Cite this