TY - JOUR
T1 - Ruffini endings are absent from the periodontal ligament of trkB knockout mice
AU - Matsuo, Saburou
AU - Ichikawa, Hiroyuki
AU - Silos-Santiago, Inmaculada
AU - Kiyomiya, Ken Ichi
AU - Kurebe, Masaru
AU - Arends, Joop J.A.
AU - Jacquin, Mark F.
PY - 2002
Y1 - 2002
N2 - To clarify the role of neurotrophin receptors in the development of Ruffini endings, periodontal ligaments and trigeminal ganglia of trkA, trkB, and trkC knockout mice were immunostained for protein gene product 9.5 (PGP 9.5), calcitonin gene-related peptide (CGRP), parvalbumin (PV), and calretinin (CR). Innervation patterns of PGP 9.5- and CGRP-immunoreactive fibers were examined in the periodontal ligament of the knockout mice. PGP 9.5-positive fibers in the incisal periodontal ligaments of trkA and trkC knockout mice form Ruffini endings distinguished by dendritic ramifications and branches. However, Ruffini endings were not present in the periodontal ligament of trkB knockout mice. Only free nerve endings were observed in tissue of trkB knockout mice. Compared with trkA and trkC knockouts, the proportion of CR-positive neurons in mandibular and maxillary regions of the trigeminal ganglion of trkB knockout mice is decreased. These findings indicate that the development of periodontal Ruffini endings is regulated by trkB-dependent and CR-coexpressing neurons.
AB - To clarify the role of neurotrophin receptors in the development of Ruffini endings, periodontal ligaments and trigeminal ganglia of trkA, trkB, and trkC knockout mice were immunostained for protein gene product 9.5 (PGP 9.5), calcitonin gene-related peptide (CGRP), parvalbumin (PV), and calretinin (CR). Innervation patterns of PGP 9.5- and CGRP-immunoreactive fibers were examined in the periodontal ligament of the knockout mice. PGP 9.5-positive fibers in the incisal periodontal ligaments of trkA and trkC knockout mice form Ruffini endings distinguished by dendritic ramifications and branches. However, Ruffini endings were not present in the periodontal ligament of trkB knockout mice. Only free nerve endings were observed in tissue of trkB knockout mice. Compared with trkA and trkC knockouts, the proportion of CR-positive neurons in mandibular and maxillary regions of the trigeminal ganglion of trkB knockout mice is decreased. These findings indicate that the development of periodontal Ruffini endings is regulated by trkB-dependent and CR-coexpressing neurons.
KW - Immunohistochemistry
KW - Incisor
KW - Mechanoreceptor
KW - Periodontal ligament
KW - Ruffini endings
KW - trkB
UR - http://www.scopus.com/inward/record.url?scp=0036397283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036397283&partnerID=8YFLogxK
U2 - 10.1080/0899022021000009134
DO - 10.1080/0899022021000009134
M3 - Article
C2 - 12396578
AN - SCOPUS:0036397283
VL - 19
SP - 213
EP - 217
JO - Somatosensory and Motor Research
JF - Somatosensory and Motor Research
SN - 0899-0220
IS - 3
ER -