Ruffini endings are absent from the periodontal ligament of trkB knockout mice

Saburou Matsuo, Hiroyuki Ichikawa, Inmaculada Silos-Santiago, Ken Ichi Kiyomiya, Masaru Kurebe, Joop J.A. Arends, Mark F. Jacquin

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

To clarify the role of neurotrophin receptors in the development of Ruffini endings, periodontal ligaments and trigeminal ganglia of trkA, trkB, and trkC knockout mice were immunostained for protein gene product 9.5 (PGP 9.5), calcitonin gene-related peptide (CGRP), parvalbumin (PV), and calretinin (CR). Innervation patterns of PGP 9.5- and CGRP-immunoreactive fibers were examined in the periodontal ligament of the knockout mice. PGP 9.5-positive fibers in the incisal periodontal ligaments of trkA and trkC knockout mice form Ruffini endings distinguished by dendritic ramifications and branches. However, Ruffini endings were not present in the periodontal ligament of trkB knockout mice. Only free nerve endings were observed in tissue of trkB knockout mice. Compared with trkA and trkC knockouts, the proportion of CR-positive neurons in mandibular and maxillary regions of the trigeminal ganglion of trkB knockout mice is decreased. These findings indicate that the development of periodontal Ruffini endings is regulated by trkB-dependent and CR-coexpressing neurons.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalSomatosensory and Motor Research
Volume19
Issue number3
DOIs
Publication statusPublished - 2002 Oct 22
Externally publishedYes

Keywords

  • Immunohistochemistry
  • Incisor
  • Mechanoreceptor
  • Periodontal ligament
  • Ruffini endings
  • trkB

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems

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