Rosiglitazone protects against cyclosporine-induced pancreatic and renal injury in rats

Byung Ha Chung, Can Li, Bo Kyung Sun, Sun Woo Lim, Kyung Ohk Ahn, Ji Hun Yang, Yoon Hee Choi, Kun Ho Yoon, Akira Sugawara, Sadayoshi Ito, Jin Kim, Chul Woo Yang

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

Rosiglitazone (RGTZ) has protective effect against various types of injury. This study was performed to evaluate the effect of RGTZ on pancreatic and renal injury caused by cyclosporine (CsA). CsA (15 mg/kg) and RGTZ (3 mg/kg) were administered alone and together to the rats for 28 days. The effect of RGTZ on CsA-induced pancreatic injury was evaluated by intraperitoneal glucose tolerance test (IPGTT), plasma insulin concentrations and pancreatic β-cell morphology. The effect of RGTZ on CsA-induced renal injury was evaluated by assessing renal function and pathology; mediators of inflammation and fibrosis such as angiotensin II (AngII), osteopontin (OPN) and transforming growth factor-beta 1 (TGF-β 1) and apoptotic cell death. Four weeks of CsA treatment caused diabetes, renal dysfunction, typical pathologic lesions (arteriolopathy, interstitial fibrosis and inflammatory cells infiltration) and apoptotic cell death. RGTZ treatment decreased blood glucose concentration, increased plasma insulin concentration and preserved pancreatic β islet mass. RGTZ treatment improved renal function and histopathology. Pro-inflammatory and pro-fibrotic molecules such as AngII, OPN and TGF-β 1, and apoptotic cell death also decreased with RGTZ treatment. These data suggest that RGTZ has a protective effect against CsA-induced pancreatic and renal injury.

Original languageEnglish
Pages (from-to)1856-1867
Number of pages12
JournalAmerican Journal of Transplantation
Volume5
Issue number8
DOIs
Publication statusPublished - 2005 Aug

Keywords

  • Cyclosporine
  • Diabetes mellitus
  • Nephrotoxicity
  • Rosiglitazone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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