Roles of the cytoskeleton, cell adhesion and rho signalling in mechanosensing and mechanotransduction

Kazumasa Ohashi, Sachiko Fujiwara, Kensaku Mizuno

    Research output: Contribution to journalReview articlepeer-review

    67 Citations (Scopus)

    Abstract

    All cells sense and respond to various mechanical forces in and mechanical properties of their environment. To respond appropriately, cells must be able to sense the location, direction, strength and duration of these forces. Recent progress in mechanobiology has provided a better understanding of the mechanisms of mechanoresponses underlying many cellular and developmental processes. Various roles of mechanoresponses in development and tissue homeostasis have been elucidated, and many molecules involved in mechanotransduction have been identified. However, the whole picture of the functions and molecular mechanisms of mechanotransduction remains to be understood. Recently, novel mechanisms for sensing and transducing mechanical stresses via the cytoskeleton, cell-substrate and cell-cell adhesions and related proteins have been identified. In this review, we outline the roles of the cytoskeleton, cell-substrate and cell-cell adhesions, and related proteins in mechanosensing and mechanotransduction. We also describe the roles and regulation of Rho-family GTPases in mechanoresponses.

    Original languageEnglish
    Pages (from-to)245-254
    Number of pages10
    JournalJournal of biochemistry
    Volume161
    Issue number3
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Actin
    • Cell adhesion
    • Cytoskeleton
    • Mechanobiology
    • rho

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology

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