Roles of MAPKKK ASK1 in stress-induced cell death

Kohsuke Takdea, Atsushi Matsuzawa, Hideki Nishitoh, Hidenori Ichijo

Research output: Contribution to journalReview articlepeer-review

183 Citations (Scopus)

Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated protein (MAP) kinase kinase kinase that activates the c-Jun N-terminal kinase (JNK) and p38 MAP kinase signaling cascades. Recent findings from analyses of ASK1-deficient mice have revealed that ASK1 is required for apoptosis induced by oxidative stress, TNF and endoplasmic reticulum (ER) stress. In addition, several lines of evidence have suggested that ASK1 has diverse functions in the decision of cell fate beyond its pro-apoptotic activity. Thus, ASK1 appears to be a pivotal component not only in stress-induced cell death but also in a broad range of biological activities in order for cells to adapt to or oppose various stresses.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalCell structure and function
Volume28
Issue number1
DOIs
Publication statusPublished - 2003 Feb

Keywords

  • ASK1
  • Apoptosis
  • JNK
  • MAPKKK
  • P38

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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